How to Cure Aging – During Your Lifetime?

by birtanpublished on September 8, 2020

Health is the most valuable thing we have in life but we tend to forget that until we lose it we're living longer than ever before which is great but an unforeseen consequence of this is that we also spend a larger and larger portion of our lives being sick getting

Old currently means spending more time in pain so scientists are trying to shift the attention of the medical community from optimizing lifespans to optimizing health spans the part of our lives during which we're disease free to

Do this we need to attack the root cause of almost all bodily defects aging itself unbeknown to most people the science of Aging has made enormous progress in the last few years with human trials about to begin in the near

Future let's look at three examples of discoveries that might benefit people who are alive right now one senescent cells your cells have an expiration date each time one of your

Cells divides it copies its chromosomes because of the way this works they lose a tiny bit of DNA at the ends this could be catastrophic so to protect themselves we have long segments of DNA called telomeres that sort of act like the

Stiff bits at the end of shoelaces but they shrink with every cell division in some cells after a number of divisions the telomeres are gone and the cell becomes a zombie the senescence cell senescence cells stay around and don't

Die the older you get the more of the MER are inside you they harmed tissue around them and are linked to many diseases that accompany old age like diabetes and kidney failure but what if you could kill them off scientists

Genetically engineered mice so that they could destroy their senescence cells as they pleased older mice without senescence cells were more active their hearts and kidneys worked better and they were less prone to cancer overall

They lived up to 30 percent longer and in better health than average mice since we can't genetically engineer all of the cells in the human body we need to find another way to get rid of our senescence cells but how do we kill them without

Harming healthy cells most cells in the body commit a programmed cell suicide when they're damaged but senescence cells don't it turns out that they under produce a protein that tells them when it's time to die so in a late 2016 study

Mice were given an injection of this protein it killed 80 percent of all their senescence cells while causing almost no harm to healthy cells the treated mice became Germany healthier and even regrew lost hair as a result

There are a number of new companies looking at treatments involving senescence cells and the first human trials will start soon to NAD+ cells are made for hundreds of millions of parts there the structures

Machines messages and the catalysts that make reactions happen all these parts constantly need to be destroyed cleaned up and rebuilt as we age this process becomes less effective and so parts become crumpled bunched up or are

Removed slower or they are no longer produced in the quantities we need one of these parts is an ad plus a coenzyme that tells ourselves to look after themselves as age 50 we only have about half as much in our bodies as we do at

Age 20 low amounts of it are linked to a whole bunch of diseases from skin cancer to Alzheimer's cardiovascular disease and multiple sclerosis but NAD+ can't enter cells so we can't get it as a pill but scientists notice that other more

Flexible substances could enter cells and would then turn into an AV plus insight in 2016 multiple trials on mice showed that they boosted the multiplication of skin brain and muscle stem cells they were rejuvenated had a

Higher ability to repair their DNA and had a slightly increased lifespan this even got NASA interested which is looking for a way to minimize the DNA damage astronauts would be exposed to from cosmic radiation on Mars missions

There are human trials being planned right now but it's too soon to say if this will boost our health span or even lifespan but NAD+ is a serious candidate and could become the first human anti-aging pill three stem cells

Stem cells are like cell blueprints that sit at various places in the body and copy themselves to produce a steady flow of fresh young cells but they decline as we age and so we decline to without new parts human bodies break in mice

Scientists observed that as the stem cells in their brains disappeared they started to develop diseases so they took stem cells from baby mice brains and injected them directly into the brains of middle-aged mice

More specifically the hypothalamus a part that involved in regulating a lot of bodily functions the fresh stem cells reinvigorated older brain cells by secreting micro rnas that regulated their metabolism after four months brain

And muscles worked better than those of untreated mice and on average they lived ten percent longer another study took stem cells from mice embryos and injected little directly into the hearts of older mice as a consequence they had

Improved heart function could exercise 20% longer and whiffy enough their hair regrew faster what all of this tells us is that there is not a single magic bullet with which to cure aging it requires a complex

Array of different therapies we can kill off senescence cells to clear away the junk give ourselves fresh new stem cells to fill the gap all while regulating the metabolism of the other cells using medication this

Video comes with a big caveat after all these studies have been carried out on mice there's no guarantee the same therapies would work in us to the same extent but they are proof of concepts to learn more about how we can modify our

Own healthspan we need human trials we've only covered a tiny part of the research that's being done right now and only scratched the surface of these ideas the field of healthspan extension needs more

Attention and funding if it gets it all of us might enjoy growing old without lane if you now want to support the research on Aging directly you can do so at lifespan dot IO a community of people actively supporting the scientists

Working to cure aging check them out to learn about the latest advances and visit their blog or group on Facebook the lifespan team also kindly supported the creation of this video with a donation and their expertise if you want

To help us make more of our videos you can do so on patreon calm

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