Could the Polio Vaccine Save the World (…Again)

published on July 9, 2020

Could a polio vaccine help us by kobannineteen when I first heard that idea Ithought there's no way polio has nothingto do with coronaviruses turns out it'snot as crazy an idea as I first thoughtI called up one of the researchers who'sproposing it dr Robert Gallo dr Gallo

Was one of the co discoverers of HIV andhe is a huge name in biomedical researchthis has a chance a moment like this isfor a decisive action and we think ithas a real chance of stopping theepidemic so how could have axion for

Polio keep you from contracting andtotally unrelated disease generallyspeaking it comes down to what the oralpolio vaccine does to your immune systemmore specifically how it interacts withyour innate immune system versus your

Adaptive immune systemthink of your favorite spy movie youknow like when the spy is invading thecompound like James Bond's trying to getin to sneak into the the base of the badguy the innate immune system is kind of

More like the guard dog that's you knowwalking around it's it's notspecifically looking for a James Bondbut it knows that anybody who comes overthe wall wearing a ski mask it needs toget bit your innate immune system is the

Guard dog it's not looking for anythingspecific it just attacks anything thatlooks dangerous I would say the adaptiveresponse is more like a sort of aSpecial Forces sniper it has the pictureof James Bond it knows what James Bond

Looks like and it was exactly whothey're targeting when you give someoneany form of a vaccine you're trainingthe sniper you're giving your adaptiveimmune system a picture of the virus andsaying next time you see this kill it

The oral polio vaccine doesn't justtrain the sniperit also startles the guard dog that'sbecause it's what's called a liveattenuated vaccine a live attenuatedvaccine contains a complete virus or

Bacteria that's been weakened in the labit wakes up the guard dog and that guarddogis angry or to use actual scientificterms hereit activates your innate immune response

Unlike the oral polio vaccine the poliovaccine you have injected is not liveand attenuated it's what's called aninactivevaccine inactivated vaccines don't usecomplete live virus and bacteria they're

Made using a physical process like heator chemicals like formaldehyde toinactivate little pieces of bacteria orviruses those pieces great at buildingadaptive immunity but they don't reallyspook the guard dog so the idea here is

That the oral polio vaccine would amp upyour innate immune response which wouldrelease that guard dog on Tsarskoe v2now you might be wondering why yourinnate immune system isn't just doingthat on its own why would it need help

From a live attenuated vaccine to stopKovan so it turns out that high schoo v2can make your innate immune system actkind of erratically and even block itfrom responding that causes lunginflammation and fluid buildup that you

Would see in severe Kovach cases takingthe oral polio vaccine might help keepthat from happeningyou could fight off the virus earlybefore it really establishes a goodinfection and then later on hopefully

That's enough to prevent thisinflammatory lung destruction thathappens on in the in the later processof Tsarskoe b2 infection so the bigquestion is will the live attenuatedoral polio vaccine wake up your innate

Immune systems guard dog enough toprevent you from getting kovin 19 thishas a chance if it works my hundredpercent sure no I'm a hundred percentsure of almost nothing so you know notonly percent sure but we think it has a

Real chance of stopping the epidemic soI think we're looking at interventionsthat might buy us a little bit of timebut for a bonafide Tsarskoe betweenvaccine emerges in 2021 hopefully I alsowant to mention that the oral polio

Vaccine is not the only live attenuatedvaccine that's being considered vaccinesfor tuberculosis and measles are also inthe mix and the idea is that they wouldalso boost your innate immune responseeven in the best case scenario these

Options are really only going to protectyou in the shortso maybe for a few months at a time thatmeans that you would have to take themevery few months until there's a vaccinefor Tsarskoe b2 available and when you

Develop a very good coronavirus vaccinewhich is specific which is long lastingthat would be great but the truth of thematter is we can't it's certainly not intime for this epidemic and further truthof the matter is you never can give a

Date for a vaccine I mean I hear a lotof suggestions for about the months willtake to get it but reality is you have avaccine when you have a vaccine so atthe end of the day these are really justbuying as time you can buy us even more

Time by staying home washing your handsavoiding large gatherings keeping yourdistance from other people and wearing amask maybe just sit on your couch andbinge your favorite American ChemicalSociety YouTube series

Stay safe everyone

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